Early intervention with high-dose acyclovir treatment during primary herpes simplex virus infection reduces latency and subsequent reactivation in the nervous system in vivo.

@article{Sawtell2001EarlyIW,
  title={Early intervention with high-dose acyclovir treatment during primary herpes simplex virus infection reduces latency and subsequent reactivation in the nervous system in vivo.},
  author={Nancy M. Sawtell and Richard. Thompson and Lawrence R Stanberry and David I. Bernstein},
  journal={The Journal of infectious diseases},
  year={2001},
  volume={184 8},
  pages={964-71}
}
There remains a lack of agreement on the effect of antiviral therapy on herpes simplex virus (HSV) latency and subsequent reactivation. To gain insight into this important issue, a single-cell polymerase chain reaction assay was used to quantify the effects of high-dose acyclovir on latent infection in a mouse model. Treatment with 50 mg/kg of acyclovir every 8 h reduced the number of latently infected neurons by >90% when treatment was begun before 24 h after infection and by 80% and 70% when… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 34 references

Herpes simplex virus: the importance of asymptomatic shedding.

The Journal of antimicrobial chemotherapy • 2000
View 1 Excerpt

A 350 bp region of the HSV ICP0 promoter is required for reactivation in vivo but not ex vivo [abstract 2.017

NM Sawtell
Publishing Services Burea, • 1999
View 2 Excerpts

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