Early intermittent noninvasive ventilation for acute chest syndrome in adults with sickle cell disease: a pilot study

@article{Fartoukh2010EarlyIN,
  title={Early intermittent noninvasive ventilation for acute chest syndrome in adults with sickle cell disease: a pilot study},
  author={Muriel Fartoukh and Yannick Lefort and Anoosha Habibi and Dora Bachir and Fr{\'e}d{\'e}ric Galact{\'e}ros and Bertrand Godeau and B. Ma{\^i}tre and L. Brochard},
  journal={Intensive Care Medicine},
  year={2010},
  volume={36},
  pages={1355-1362}
}
Alveolar hypoxia and hypoxic vasoconstriction lead to trapping of sickle cells within the pulmonary vasculature. Improving alveolar ventilation and oxygenation may improve the outcome of acute chest syndrome (ACS). Prospective randomized single-center open study from November 1998 to February 2002 to test whether noninvasive ventilation (NIV) was more effective than oxygen alone in improving oxygenation on day 3 in adults with ACS and to evaluate the effects on pain, transfusion requirements… CONTINUE READING

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