Early innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits

@inproceedings{Subbian2013EarlyII,
  title={Early innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits},
  author={Selvakumar Subbian and Nirmalya Bandyopadhyay and Liana Georgieva Tsenova and Paul T. O’Brien and Viraj Khetani and Nicole L. Kushner and Blas Peixoto and Patricia Soteropoulos and Joel S. Bader and Petros C Karakousis and Dorothy Fallows and Gilla Kaplan},
  booktitle={Cell Communication and Signaling},
  year={2013}
}
Pulmonary infection of humans by Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), results in active disease in 5-10% of individuals, while asymptomatic latent Mtb infection (LTBI) is established in the remainder. The host immune responses that determine this differential outcome following Mtb infection are not fully understood. Using a rabbit model of pulmonary TB, we have shown that infection with the Mtb clinical isolate HN878 (a hyper-virulent W-Beijing lineage… CONTINUE READING

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