Early initiation of external beam radiotherapy (EBRT) may increase the risk of long-term toxicity in patients undergoing intraoperative radiotherapy (IORT) as a boost for breast cancer.

@article{Wenz2008EarlyIO,
  title={Early initiation of external beam radiotherapy (EBRT) may increase the risk of long-term toxicity in patients undergoing intraoperative radiotherapy (IORT) as a boost for breast cancer.},
  author={Frederik Wenz and Grit Welzel and Anke Keller and Elena Blank and Fatemeh Vorodi and Carsten Herskind and Oliver Tom{\'e} and Marc Wolf S{\"u}tterlin and Uta Kraus-Tiefenbacher},
  journal={Breast},
  year={2008},
  volume={17 6},
  pages={617-22}
}
BACKGROUND Intraoperative radiotherapy (IORT) during breast-conserving surgery is increasingly used. We analyzed the influence of the interval between an IORT boost and external beam radiotherapy (EBRT) on late toxicity. METHODS Forty-eight patients received 20 Gy IORT (50 kV X-rays (Intrabeam, Carl Zeiss, Oberkochen, Germany) followed by 46-50 Gy EBRT with a median interval of 36 days (14-197). Late toxicity was assessed with the modified LENT SOMA score after a median of 36 months… CONTINUE READING

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Boost IORT in Breast Cancer: Body of Evidence

International journal of breast cancer • 2014

Intraoperative radiotherapy in breast conserving surgery.

Journal of surgical oncology • 2014
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Biologischer Effekt niederenergetischer Röntgenstrahlung als intraoperativer Boost in Kombination mit externer Strahlentherapie

C Herskind, Q Liu, +3 authors F. Wenz
Strahlenther Onkol 2008;184(S1):117e8 • 2008
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