Early initiation of combined antiretroviral therapy preserves immune function in the gut of HIV-infected patients

@article{Kk2015EarlyIO,
  title={Early initiation of combined antiretroviral therapy preserves immune function in the gut of HIV-infected patients},
  author={Ayrin K{\"o}k and Laurent Hocqueloux and Hakim Hocini and Matthieu Carri{\`e}re and Laurent Lefrou and Aur{\'e}lie Guguin and Pascaline Tisserand and Henri Bonnabau and V{\'e}ronique Avettand-Fenoel and Thi{\'e}rry Prazuck and Sandrine Katsahian and Ph Gaulard and Rodolphe Thi{\'e}baut and Yves L{\'e}vy and Sophie H{\"u}e},
  journal={Mucosal Immunology},
  year={2015},
  volume={8},
  pages={127-140}
}
Massive loss of lamina propria CD4+ T cells, changes in the lymphatic architecture, and altered intestinal epithelial barrier leading to microbial translocation are the common features of HIV-1 infection and are not fully restored under combined antiretroviral therapy (cART). To better understand determinants of gut mucosal restoration, we have performed phenotypic and gene expression analyses of the gut from HIV-infected patients, naive or treated with cART initiated either at the early phase… CONTINUE READING