Early initiation of a replication origin tethered at the nuclear periphery.

@article{Ebrahimi2010EarlyIO,
  title={Early initiation of a replication origin tethered at the nuclear periphery.},
  author={Hani Ebrahimi and E. Douglas Robertson and Angela Taddei and Susan M. Gasser and Anne D. Donaldson and Shin-ichiro Hiraga},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 7},
  pages={
          1015-9
        }
}
Peripheral nuclear localization of chromosomal loci correlates with late replication in yeast and metazoan cells. To test whether peripheral positioning can impose late replication, we examined whether artificial tethering of an early-initiating replication origin to the nuclear periphery delays its replication in budding yeast. We tested the effects of three different peripheral tethering constructs on the time of replication of the early replication origin ARS607. Using the dense-isotope… CONTINUE READING

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