Early inflammatory response of minocycline and tetracycline on the rabbit pleura.

  title={Early inflammatory response of minocycline and tetracycline on the rabbit pleura.},
  author={S R Dryzer and Jeffrey Joseph and Michael Baumann and Karen Birmingham and Steven A. Sahn and Charlie Strange},
  volume={104 5},
The histopathologic findings were compared from 20 mg/kg intrapleural tetracycline hydrochloride (TCN) and three doses of intrapleural minocycline hydrochloride (5, 10, and 20 mg/kg) (MCN) in New Zealand white rabbits. Both TCN and MCN produced an early neutrophilic predominant pleural effusion that became mononuclear over 48 h. There was no difference in pleural fluid accumulation, number of adhesions, or histologically measured visceral and parietal pleural thickness between TCN and MCN (all… CONTINUE READING
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