Early infancy microbial and metabolic alterations affect risk of childhood asthma

  title={Early infancy microbial and metabolic alterations affect risk of childhood asthma},
  author={M. Arrieta and Leah T. Stiemsma and Pedro A. Dimitriu and L. Thorson and S. Russell and Sophie Yurist-Doutsch and Boris Kuzeljevic and Matthew J. Gold and Heidi M. Britton and D. Lefebvre and P. Subbarao and P. Mandhane and A. Becker and Kelly M. McNagny and M. Sears and Tobias Kollmann and W. Mohn and S. Turvey and B. Brett Finlay},
  journal={Science Translational Medicine},
  pages={307ra152 - 307ra152}
  • M. Arrieta, Leah T. Stiemsma, +16 authors B. Brett Finlay
  • Published 2015
  • Biology, Medicine
  • Science Translational Medicine
  • Supplementing bacterial genera reduced in infants at high risk for asthma ameliorates lung inflammation in mice. Window of opportunity for asthma Changes in the gut microbiota have been implicated in the development of asthma in animal models; however, it has remained unclear whether these findings hold true in humans. Now, Arrieta et al. report in a longitudinal human study that infants at risk of asthma have transient gut microbial dysbiosis during the first 100 days of life. They found that… CONTINUE READING
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