Early induction of autophagy in human fibroblasts after infection with human cytomegalovirus or herpes simplex virus 1.

@article{Mcfarlane2011EarlyIO,
  title={Early induction of autophagy in human fibroblasts after infection with human cytomegalovirus or herpes simplex virus 1.},
  author={S. Mcfarlane and James Aitken and Jane S Sutherland and Mary Jane Nicholl and Valerie G. Preston and Chris Preston},
  journal={Journal of virology},
  year={2011},
  volume={85 9},
  pages={
          4212-21
        }
}
The infection of human fetal foreskin fibroblasts (HFFF2) with human cytomegalovirus (HCMV) resulted in the induction of autophagy. This was demonstrated by the increased lipidation of microtubule-associated protein 1 light chain 3 (LC3), a hallmark of autophagy, and by the visualization of characteristic vesicles within infected cells. The response was detected first at 2 h postinfection and persisted for at least 3 days. De novo protein synthesis was not required for the effect, since HCMV… CONTINUE READING
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