Early induction of CREB activation and CREB-regulating signalling by antidepressants.

  title={Early induction of CREB activation and CREB-regulating signalling by antidepressants.},
  author={Daniela Tardito and Laura Musazzi and Ettore Tiraboschi and Alessandra Mallei and Giorgio Racagni and Maurizio Popoli},
  journal={The international journal of neuropsychopharmacology},
  volume={12 10},
Converging evidence points to adaptive changes in neuroplasticity and gene expression as mediators of therapeutic action of antidepressants. Activation of cAMP response-element binding protein (CREB) and CREB-regulating signalling are considered main effectors in these mechanisms. We analysed the temporal profile of intracellular changes induced by antidepressants, by measuring activation of major CREB-regulating signalling cascades and activation (Ser133 phosphorylation) of CREB. The main aims… 

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