Early induction by crotoxin of biphasic frequency changes and giant miniature endplate potentials in frog muscle.

@article{Hawgood1988EarlyIB,
  title={Early induction by crotoxin of biphasic frequency changes and giant miniature endplate potentials in frog muscle.},
  author={Barbara J Hawgood and I. Christopher H. Smith and Peter N. Strong},
  journal={British journal of pharmacology},
  year={1988},
  volume={94 3},
  pages={765-72}
}
1. Following the addition of crotoxin (250 nM) at the frog neuromuscular junction, there was an initial fall in frequency of miniature endplate potentials (m.e.p.ps), followed by a secondary rise which was characterized by the appearance of large spontaneous potentials (giants, g.m.e.p.ps) and an occasional large potential of the burst type. 2. In the presence of 2-(4-phenylpiperidino)cyclohexanol (AH5183, vesicamol), an inhibitor of vesicular acetylcholine uptake, the frequency of g.m.e.p.ps… CONTINUE READING