Early impairment of skeletal muscle endothelial glycocalyx barrier properties in diet‐induced obesity in mice

@inproceedings{Eskens2014EarlyIO,
  title={Early impairment of skeletal muscle endothelial glycocalyx barrier properties in diet‐induced obesity in mice},
  author={Bart J. M. Eskens and Thomas M. Leurgans and Hans Vink and Jurgen W G E Vanteeffelen},
  booktitle={Physiological reports},
  year={2014}
}
While previous studies have indicated an important role for the endothelial glycocalyx in regulation of microvascular function, it was recently shown that acute enzymatic glycocalyx degradation in rats was associated with an impaired insulin-mediated glucose disposal. The aim of this study was to determine whether glycocalyx damage in skeletal muscle occurs at an early stage of diet-induced obesity (DIO). The microcirculation of the hindlimb muscle of anesthetized C57Bl/6 mice, fed chow (CON… CONTINUE READING
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