Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective.

Abstract

Various immune response pathways are altered during early, predegenerative stages of glaucoma; however, whether the early immune responses occur secondarily to or independently of neuronal dysfunction is unclear. To investigate this relationship, we used the Wlds allele, which protects from axon dysfunction. We demonstrate that DBA/2J.Wlds mice develop high… (More)
DOI: 10.1073/pnas.1608769114

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@article{Harder2017EarlyIR, title={Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective.}, author={Jeffrey M Harder and Catherine E. Braine and Pete A Williams and Xianjun Zhu and Katharine H. MacNicoll and Gregory L. Sousa and Rebecca A. Buchanan and Richard S. Smith and Richard T Libby and Gareth R. Howell and Simon W M John}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2017}, volume={114 19}, pages={E3839-E3848} }