Early identification of resistance to first-line single-agent methotrexate in patients with persistent trophoblastic disease.

@article{Trommel2006EarlyIO,
  title={Early identification of resistance to first-line single-agent methotrexate in patients with persistent trophoblastic disease.},
  author={Nienke E van Trommel and Leon F A G Massuger and Charles P T Schijf and Marianne J ten Kate-Booij and Fred C G J Sweep and Chris M. G. Thomas},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 1},
  pages={52-8}
}
PURPOSE A generally accepted definition for resistance to first-line single-agent chemotherapy for persistent trophoblastic disease (PTD) is lacking. In the present study, a normogram for serum human chorionic gonadotropin (hCG) from patients with normalization of serum hCG after first-line single-agent chemotherapy for PTD was constructed to identify patients resistant to this chemotherapy. PATIENTS AND METHODS Between 1987 and 2004, data from 2,132 patients were registered at the Dutch… CONTINUE READING

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