Early identification of aortic valve sclerosis using iron oxide enhanced MRI.

  title={Early identification of aortic valve sclerosis using iron oxide enhanced MRI.},
  author={Amanda M Hamilton and Kem A. Rogers and Andre J-L Belisle and John Anton Chrisostom Ronald and Brian K. Rutt and Ralph Weissleder and Derek R. Boughner},
  journal={Journal of magnetic resonance imaging : JMRI},
  volume={31 1},
PURPOSE To test the ability of MION-47 enhanced MRI to identify tissue macrophage infiltration in a rabbit model of aortic valve sclerosis (AVS). MATERIALS AND METHODS The aortic valves of control and cholesterol-fed New Zealand White rabbits were imaged in vivo pre- and 48 h post-intravenous administration of MION-47 using a 1.5 Tesla (T) MR clinical scanner and a CINE fSPGR sequence. MION-47 aortic valve cusps were imaged ex vivo on a 3.0T whole-body MR system with a custom gradient insert… CONTINUE READING

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