Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B−/− mice

@inproceedings{Peixoto2016EarlyHA,
  title={Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B−/− mice},
  author={Rui T. Peixoto and Wengang Wang and Donyell M. Croney and Yevgenia Kozorovitskiy and Bernardo L. Sabatini},
  booktitle={Nature Neuroscience},
  year={2016}
}
Some autistic individuals exhibit abnormal development of the caudate nucleus and associative cortical areas, suggesting potential dysfunction of cortico-basal ganglia (BG) circuits. Using optogenetic and electrophysiological approaches in mice, we identified a narrow postnatal period that is characterized by extensive glutamatergic synaptogenesis in striatal spiny projection neurons (SPNs) and a concomitant increase in corticostriatal circuit activity. SPNs during early development have high… CONTINUE READING