Early histone modifications in the ventromedial hypothalamus and preoptic area following oestradiol administration.

@article{Gagnidze2013EarlyHM,
  title={Early histone modifications in the ventromedial hypothalamus and preoptic area following oestradiol administration.},
  author={Khatuna Gagnidze and Zachary M. Weil and Larissa Costa Faustino and Sara M. Schaafsma and Donald W. Pfaff},
  journal={Journal of neuroendocrinology},
  year={2013},
  volume={25 10},
  pages={939-55}
}
Expression of the primary female sex behaviour, lordosis, in laboratory animals depends on oestrogen-induced expression of progesterone receptor (PgR) within a defined cell group in the ventrolateral portion of the ventromedial nucleus of the hypothalamus (VMH). The minimal latency from oestradiol administration to lordosis is 18 h. During that time, ligand-bound oestrogen receptors (ER), members of a nuclear receptor superfamily, recruit transcriptional coregulators, which induce covalent… CONTINUE READING

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