Early heart development in the chick embryo: effects of isotretinoin on cell proliferation, alpha-actin synthesis, and development of contractions.

@article{Wiens1992EarlyHD,
  title={Early heart development in the chick embryo: effects of isotretinoin on cell proliferation, alpha-actin synthesis, and development of contractions.},
  author={Darrell J. Wiens and Tejinder K Mann and D E Fedderson and W. Kimryn Rathmell and Bernard Franck},
  journal={Differentiation; research in biological diversity},
  year={1992},
  volume={51 2},
  pages={105-12}
}
Isotretinoin is a potent retinoic acid used in the treatment of skin disorders. Though very effective, it is teratogenic if administered during pregnancy, and its teratogenic effect may be related to the normal activity of retinoids as signalling molecules in the embryo. Although its exact mechanism of action is unknown, it has been suggested that it causes its characteristic pattern of defects that includes heart defects, by inhibiting the migration of neural crest cells. However, other… CONTINUE READING