Early growth response transcription factors are required for development of CD4(-)CD8(-) thymocytes to the CD4(+)CD8(+) stage.

@article{Carleton2002EarlyGR,
  title={Early growth response transcription factors are required for development of CD4(-)CD8(-) thymocytes to the CD4(+)CD8(+) stage.},
  author={Michael Carleton and Mari{\"e}lle C Haks and Sigrid A.A. Smeele and Allan P. Jones and Stanley M. Belkowski and Marc A. Berger and Peter Linsley and Ada M. Kruisbeek and David L Wiest},
  journal={Journal of immunology},
  year={2002},
  volume={168 4},
  pages={
          1649-58
        }
}
Progression of immature CD4(-)CD8(-) thymocytes beyond the beta-selection checkpoint to the CD4(+)CD8(+) stage requires activation of the pre-TCR complex; however, few of the DNA-binding proteins that serve as molecular effectors of those pre-TCR signals have been identified. We demonstrate in this study that members of the early growth response (Egr) family of transcription factors are critical effectors of the signals that promote this developmental transition. Specifically, the induction of… CONTINUE READING

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