Early growth response proteins EGR-4 and EGR-3 interact with immune inflammatory mediators NF-kappaB p50 and p65.

@article{Wieland2005EarlyGR,
  title={Early growth response proteins EGR-4 and EGR-3 interact with immune inflammatory mediators NF-kappaB p50 and p65.},
  author={Gerhard D Wieland and Nina Nehmann and Doreen Mueller and Hermann Eibel and Ulrich K Siebenlist and J{\"u}rgen S{\"u}hnel and Peter F Zipfel and Christine Skerka},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 14},
  pages={3203-12}
}
Here, we characterize the basis for the T-cell-specific activity of the human zinc-finger protein early growth response factor 4 (EGR-4). A yeast two-hybrid screen showed interaction of EGR-4 with NF-kappaB p50. Using recombinant proteins, stable physical complex formation was confirmed for EGR-4 and EGR-3 with p50 and with p65 using glutathione-S-transferase pull-down assays and surface-plasmon-resonance and peptide-spot analyses. In vivo interaction of EGR-4 and EGR-3 with NF-kappaB p65 was… CONTINUE READING

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