Early growth response gene-2 controls IL-17 expression and Th17 differentiation by negatively regulating Batf.


Early growth response gene (Egr)-2 is important for the maintenance of T cell homeostasis and controls the development of autoimmune disease. However, the underlying mechanisms are unknown. We have now discovered that Egr-2, which is induced by TGF-β and IL-6, negatively regulates the expression of IL-17, but not IL-2 or IFN-γ, in effector T cells. In the… (More)
DOI: 10.4049/jimmunol.1200868


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