Early growth response gene-2 controls IL-17 expression and Th17 differentiation by negatively regulating Batf.

@article{Miao2013EarlyGR,
  title={Early growth response gene-2 controls IL-17 expression and Th17 differentiation by negatively regulating Batf.},
  author={Tizong Miao and Meera V. Raymond and Punamdip Bhullar and Emma Ghaffari and Alistair L J Symonds and Ute C. Meier and Gavin Giovannoni and Suling Li and Ping Wang},
  journal={Journal of immunology},
  year={2013},
  volume={190 1},
  pages={58-65}
}
Early growth response gene (Egr)-2 is important for the maintenance of T cell homeostasis and controls the development of autoimmune disease. However, the underlying mechanisms are unknown. We have now discovered that Egr-2, which is induced by TGF-β and IL-6, negatively regulates the expression of IL-17, but not IL-2 or IFN-γ, in effector T cells. In the absence of Egr-2, CD4 T cells produce high levels of Th17 cytokines, which renders mice susceptible to experimental autoimmune… CONTINUE READING
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