Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2.

@article{Santiago1999EarlyGR,
  title={Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2.},
  author={Fernando S. Santiago and Harry C. Lowe and F L Day and Colin N. Chesterman and Levon M. Khachigian},
  journal={The American journal of pathology},
  year={1999},
  volume={154 3},
  pages={
          937-44
        }
}
Cell migration and proliferation that follows injury to the artery wall is preceded by signaling and transcriptional events that converge at the promoters of multiple genes whose products can influence formation of the neointima. Transcription factors, such as early growth response factor-1 (Egr-1), with nucleotide recognition elements in the promoters of many pathophysiologically relevant genes, are expressed at the endothelial wound edge within minutes of injury. The mechanisms underlying the… CONTINUE READING

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High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis.

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