Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence.

@article{KronesHerzig2003EarlyGR,
  title={Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence.},
  author={Anja Krones-Herzig and Eileen Adamson and Dan Mercola},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 6},
  pages={3233-8}
}
The proliferation of most primary cells in culture is limited by replicative senescence and crisis, p53-dependent events. However, the regulation of p53 itself has not been defined. We find that deletion of the early growth response 1 (EGR1) transcription factor leads to a striking phenotype, including complete bypass of senescence and apparent immortal growth consistent with loss of a suppressor gene. EGR1-null mouse embryo fibroblasts (MEFs) exhibit decreased expression of p53, p21(Cip1/Waf1… CONTINUE READING