Early growth response 1 (Egr1) regulates cholesterol biosynthetic gene expression.

@article{Gokey2011EarlyGR,
  title={Early growth response 1 (Egr1) regulates cholesterol biosynthetic gene expression.},
  author={Nolan G Gokey and Camila Lopez-Anido and Anne Lynn Gillian-Daniel and John Svaren},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 34},
  pages={29501-10}
}
The early growth response (EGR) family of transcription factors has been implicated in control of lipid biosynthetic genes. Egr1 is induced by insulin both in vitro and in vivo and is the most highly expressed family member in liver. In this study, we investigated whether Egr1 regulates cholesterol biosynthetic genes in liver. Using an insulin-sensitive liver cell line, we show that localization of Egr1 to cholesterol biosynthetic genes is induced by insulin treatment and that this localization… CONTINUE READING