Early growth determines longevity in male rats and may be related to telomere shortening in the kidney.

@article{Jennings1999EarlyGD,
  title={Early growth determines longevity in male rats and may be related to telomere shortening in the kidney.},
  author={Bridget J Jennings and Susan E Ozanne and M W Dorling and Charles Nicholas Hales},
  journal={FEBS letters},
  year={1999},
  volume={448 1},
  pages={
          4-8
        }
}
Maternal protein undernutrition can influence the growth and longevity of male offspring in the rat. We tested the hypothesis that these differences in longevity were associated with changes in the rate of telomere shortening. We found age-related shortening of telomeres in the liver and kidney but not in the brain of male rats. Growth retardation in postnatal life was associated with significantly longer kidney telomeres and an increased longevity. Conversely, growth retardation during the… CONTINUE READING

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