Early goal-directed therapy vs usual care in the treatment of severe sepsis and septic shock: a systematic review and meta-analysis

@article{Rusconi2015EarlyGT,
  title={Early goal-directed therapy vs usual care in the treatment of severe sepsis and septic shock: a systematic review and meta-analysis},
  author={A. M. Rusconi and I. Bossi and J. G. Lampard and M. Szava-Kovats and A. Bellone and E. Lang},
  journal={Internal and Emergency Medicine},
  year={2015},
  volume={10},
  pages={731-743}
}
Sepsis is a common and high-burden healthcare problem with a mortality exceeding 20 % in severe sepsis and nearly 50 % when septic shock is present. Early goal-directed therapy (EGDT) is recommended by sepsis guidelines as the standard of care following a landmark study by Rivers et al. alongside other observational studies. Three recent randomized controlled trials have questioned the Rivers’ results. The objective of our systematic review was to assess the effectiveness of EGDT in reducing… Expand
Septic Shock: Advances in Diagnosis and Treatment.
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