Early ghrelin treatment attenuates disruption of the blood brain barrier and apoptosis after traumatic brain injury through a UCP-2 mechanism.

@article{Lopez2012EarlyGT,
  title={Early ghrelin treatment attenuates disruption of the blood brain barrier and apoptosis after traumatic brain injury through a UCP-2 mechanism.},
  author={Nicole E. Lopez and Louise Gaston and K R Lopez and Rita de Cassia Sinigaglia Galli Coimbra and A Hageny and James G. Putnam and Brian P. Eliceiri and Vinay Bansal},
  journal={Brain research},
  year={2012},
  volume={1489},
  pages={140-8}
}
Ghrelin has been shown to be anti-inflammatory and neuroprotective in models of neurologic injury. We hypothesize that treatment with ghrelin will attenuate breakdown of the blood brain barrier (BBB) and apoptosis 24h following traumatic brain injury (TBI). We believe this protection is at least in part mediated by up-regulation of UCP-2, thereby stabilizing mitochondria and preventing up-regulation of caspase-3. A weight drop model was used to create severe TBI. Balb/c mice were divided into 3… CONTINUE READING
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