Early genetic events in T cell development analyzed by in situ hybridization

@article{Pardoll1987EarlyGE,
  title={Early genetic events in T cell development analyzed by in situ hybridization},
  author={Drew Mark Pardoll and Jonathan Fowlkes and R. Lechler and Ronald N. Germain and Ronald H. Schwartz},
  journal={The Journal of Experimental Medicine},
  year={1987},
  volume={165},
  pages={1624 - 1638}
}
In situ hybridization was used to investigate the expression of T cell receptor (TCR) alpha, beta, and gamma mRNAs in developing fetal and adult precursor thymocytes. gamma transcription was observed at the earliest time tested (day 12), followed by beta 12 h later, and TCR alpha on day 16. The early beta transcripts appeared to be from unrearranged or incompletely rearranged (D-J-C) beta loci. V beta region transcription was first detectable on day 14 and transcription of different V beta… CONTINUE READING

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