Early gene m18, a novel player in the immune response to murine cytomegalovirus.

@article{Holtappels2002EarlyGM,
  title={Early gene m18, a novel player in the immune response to murine cytomegalovirus.},
  author={Rafaela Holtappels and Natascha K. A. Grzimek and Doris Thomas and Matthias Johannes Reddehase},
  journal={The Journal of general virology},
  year={2002},
  volume={83 Pt 2},
  pages={311-6}
}
The identification of all antigenic peptides encoded by a pathogen, its T cell 'immunome', is a research aim for rational vaccine design. Screening of proteome-spanning peptide libraries or computational prediction is used to identify antigenic peptides recognized by CD8 T cells. Based on their high coding capacity, cytomegaloviruses (CMVs) could specify numerous antigenic peptides. Yet, current evidence indicates that the memory CD8 T cell response in a given haplotype is actually focused on a… CONTINUE READING