Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus

@article{Geck1999EarlyGE,
  title={Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus},
  author={Peter Geck and Jozsef Szelei and Jes{\'u}s Villar Jim{\'e}nez and Carlos Sonnenschein and Ana M. Soto},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1999},
  volume={68},
  pages={41-50}
}
In the prostate gland cell numbers are regulated by androgens through three separate pathways: (a) inhibition of cell death (apoptosis), (b) induction of cell proliferation (step 1), and (c) inhibition of cell proliferation (step 2, proliferative shutoff). The precise regulation of these control pathways is still elusive. The human prostate carcinoma LNCaP cell line variants express a subset of proliferative pathways comparable to those present in normal prostate cells (LNCaP-FGC expresses both… CONTINUE READING

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