Early gamma interferon and interleukin-2 responses to vaccination predict the late resting memory in malaria-naïve and malaria-exposed individuals.

@article{Bejon2006EarlyGI,
  title={Early gamma interferon and interleukin-2 responses to vaccination predict the late resting memory in malaria-na{\"i}ve and malaria-exposed individuals.},
  author={Philip Bejon and Sheila A Keating and Jedidah K Mwacharo and Oscar K Kai and Susanna J Dunachie and Michael J. Walther and Tamara K. Berthoud and Trudie Lang and Judy Epstein and Daniel J. Carucci and Philippe J. Moris and Joe Cohen and Sarah C Gilbert and Norbert Peshu and Kevin Marsh and Adrian V S Hill},
  journal={Infection and immunity},
  year={2006},
  volume={74 11},
  pages={
          6331-8
        }
}
Two different cell populations respond to potent T-cell-inducing vaccinations. The induction and loss of effector cells can be seen using an ex vivo enzyme-linked immunospot (ELISPOT) assay, but the more durable resting memory response is demonstrable by a cultured ELISPOT assay. The relationship of the early effector response to durable resting memory is incompletely understood. Effector phenotype is usually identified by gamma interferon (IFN-gamma) production, but interleukin-2 (IL-2) has… CONTINUE READING

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