Early frontotemporal dementia targets neurons unique to apes and humans

@article{Seeley2006EarlyFD,
  title={Early frontotemporal dementia targets neurons unique to apes and humans},
  author={William W. Seeley and Danielle Carlin and John Allman and Marcelo N. Macedo and Clarissa Bush and Bruce L. Miller and Stephen J. DeArmond},
  journal={Annals of Neurology},
  year={2006},
  volume={60}
}
Frontotemporal dementia (FTD) is a neurodegenerative disease that erodes uniquely human aspects of social behavior and emotion. The illness features a characteristic pattern of early injury to anterior cingulate and frontoinsular cortex. These regions, though often considered ancient in phylogeny, are the exclusive homes to the von Economo neuron (VEN), a large bipolar projection neuron found only in great apes and humans. Despite progress toward understanding the genetic and molecular bases of… 
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The results suggest that the behavioral deficits in patients with clinical bvFTD and underlying pathological AD are not driven by the loss of von Economo neurons.
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TLDR
The aim of this study is to assess the insular cortex cellular and subregional vulnerability to α‐synuclein pathology in well‐characterized PD and DLB subjects.
Von Economo neurons are part of a larger neuronal population that are selectively vulnerable in C9orf72 frontotemporal dementia
The behavioural variant of frontotemporal dementia with a C9orf72 expansion (C9‐bvFTD) is characterised by early changes in social‐emotional cognition that are linked to the loss of von Economo
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