Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state

Abstract

Across different niches, subsets of highly functional stem cells are maintained in a relatively dormant rather than proliferative state. Our understanding of proliferative dynamics in tissue-specific stem cells during conditions of increased tissue turnover remains limited. Using a TetO-H2B-GFP reporter of proliferative history, we identify skeletal muscle… (More)
DOI: 10.1242/dev.100842

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