Early fetal hypoxia leads to growth restriction and myocardial thinning.

  title={Early fetal hypoxia leads to growth restriction and myocardial thinning.},
  author={Margie A Ream and Alisa M Ray and Rashmi Chandra and Dona M. Chikaraishi},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={295 2},
Hypoxia is necessary for fetal development; however, excess hypoxia is detrimental. Hypoxia has been extensively studied in the near-term fetus, but less is known about earlier fetal effects. The purpose of this study was to determine the window of vulnerability to severe hypoxia, what organ system(s) is most sensitive, and why hypoxic fetuses die. We induced hypoxia by reducing maternal-inspired O2 from 21% to 8%, which decreased fetal tissue oxygenation assessed by pimonidazole binding. The… CONTINUE READING
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