Early expression of the fractalkine receptor CX3CR1 in pancreatic carcinogenesis

@inproceedings{Celesti2013EarlyEO,
  title={Early expression of the fractalkine receptor CX3CR1 in pancreatic carcinogenesis},
  author={Giuseppe Celesti and Giuseppe Di Caro and Paolo Pietro Bianchi and Fabio Grizzi and Federica Marchesi and Gianluca Basso and Daoud Rahal and Gabriele Delconte and Maddalena Catalano and Paola Cappello and Massimo G. Roncalli and Alessandro Zerbi and M Montorsi and Francesco Novelli and Alberto Mantovani and Paola Allavena and Alberto Malesci and Luigi Laghi},
  booktitle={British Journal of Cancer},
  year={2013}
}
Background:In pancreatic ductal adenocarcinoma (PDAC), fractalkine receptor CX3CR1 contributes to perineural invasion (PNI). We investigated whether CX3CR1 expression occurs early in PDAC and correlates with tumour features other than PNI.Methods:We studied CX3CR1 and CX3CL1 expression by immunohistochemistry in 104 human PDAC and coexisting Pancreatic Intraepithelial Neoplasia (PanIN), and in PdxCre/LSL-KrasG12D mouse model of PDAC. CX3CR1 expression in vitro was studied by a spheroid model… CONTINUE READING

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