Early exposure to methylphenidate increases fear responses in an aversive context in adult rats.

@article{Britton2007EarlyET,
  title={Early exposure to methylphenidate increases fear responses in an aversive context in adult rats.},
  author={Gabrielle B. Britton and Andrew T. Segan and Jeffrey Sejour and Silvia E. Mancebo},
  journal={Developmental psychobiology},
  year={2007},
  volume={49 3},
  pages={265-75}
}
The effects of methylphenidate hydrochloride (MPH) administration during development on fear acquisition and retention in adulthood were examined using classical fear conditioning. Male Sprague-Dawley rats were administered MPH (2 mg/kg) or saline twice daily from postnatal day (PD) 25 to 39, and were trained and tested on PD 81 and 82. During training, shock unconditioned stimulus (US) presentations were explicitly paired with an auditory conditioned stimulus (CS) or occurred unsignaled in the… CONTINUE READING

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