Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.

@article{JevtoviTodorovi2003EarlyET,
  title={Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.},
  author={Vesna Jevtovi{\'c}-Todorovi{\'c} and Richard E Hartman and Yukitoshi Izumi and Nicholas D. Benshoff and Krikor Dikranian and Charles F Zorumski and John W. Olney and David F. Wozniak},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 3},
  pages={876-82}
}
Recently it was demonstrated that exposure of the developing brain during the period of synaptogenesis to drugs that block NMDA glutamate receptors or drugs that potentiate GABA(A) receptors can trigger widespread apoptotic neurodegeneration. All currently used general anesthetic agents have either NMDA receptor-blocking or GABA(A) receptor-enhancing properties. To induce or maintain a surgical plane of anesthesia, it is common practice in pediatric or obstetrical medicine to use agents from… CONTINUE READING
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