Early exposure of cultured hippocampal neurons to excitatory amino acids protects from later excitotoxicity.

@article{Friedman2010EarlyEO,
  title={Early exposure of cultured hippocampal neurons to excitatory amino acids protects from later excitotoxicity.},
  author={Linda K Friedman and Menahem Segal},
  journal={International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience},
  year={2010},
  volume={28 2},
  pages={195-205}
}
Status epilepticus occurring in early postnatal development protects CA1 hippocampal neurons, the region most sensitive to seizure-induced injury in the developing brain. Here, we developed a "two hit" model in dissociated cultures of the rat hippocampus to test whether pre-exposure of immature neurons to high concentrations of glutamate, N-methyl-D-aspartic acid (NMDA) or alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) during a relatively resistant period prevents neurons from… CONTINUE READING

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Status epilepticus occurring in early postnatal development protects CA1 hippocampal neurons , the region most sensitive to seizure - induced injury in the developing brain .
Status epilepticus occurring in early postnatal development protects CA1 hippocampal neurons , the region most sensitive to seizure - induced injury in the developing brain .
Status epilepticus occurring in early postnatal development protects CA1 hippocampal neurons , the region most sensitive to seizure - induced injury in the developing brain .
Here , we developed a " two hit " model in dissociated cultures of the rat hippocampus to test whether pre - exposure of immature neurons to high concentrations of glutamate , N - methyl - D - aspartic acid ( NMDA ) or alpha - amino-3-hydroxy-5-methyl-4-isoxazole - propionic acid ( AMPA ) during a relatively resistant period prevents neurons from dying following a second exposure to the same chemicals after neurons mature and become highly vulnerable to excitatory amino acids ( EAAs ) .
Here , we developed a " two hit " model in dissociated cultures of the rat hippocampus to test whether pre - exposure of immature neurons to high concentrations of glutamate , N - methyl - D - aspartic acid ( NMDA ) or alpha - amino-3-hydroxy-5-methyl-4-isoxazole - propionic acid ( AMPA ) during a relatively resistant period prevents neurons from dying following a second exposure to the same chemicals after neurons mature and become highly vulnerable to excitatory amino acids ( EAAs ) .
Here , we developed a " two hit " model in dissociated cultures of the rat hippocampus to test whether pre - exposure of immature neurons to high concentrations of glutamate , N - methyl - D - aspartic acid ( NMDA ) or alpha - amino-3-hydroxy-5-methyl-4-isoxazole - propionic acid ( AMPA ) during a relatively resistant period prevents neurons from dying following a second exposure to the same chemicals after neurons mature and become highly vulnerable to excitatory amino acids ( EAAs ) .
Here , we developed a " two hit " model in dissociated cultures of the rat hippocampus to test whether pre - exposure of immature neurons to high concentrations of glutamate , N - methyl - D - aspartic acid ( NMDA ) or alpha - amino-3-hydroxy-5-methyl-4-isoxazole - propionic acid ( AMPA ) during a relatively resistant period prevents neurons from dying following a second exposure to the same chemicals after neurons mature and become highly vulnerable to excitatory amino acids ( EAAs ) .
Here , we developed a " two hit " model in dissociated cultures of the rat hippocampus to test whether pre - exposure of immature neurons to high concentrations of glutamate , N - methyl - D - aspartic acid ( NMDA ) or alpha - amino-3-hydroxy-5-methyl-4-isoxazole - propionic acid ( AMPA ) during a relatively resistant period prevents neurons from dying following a second exposure to the same chemicals after neurons mature and become highly vulnerable to excitatory amino acids ( EAAs ) .
Here , we developed a " two hit " model in dissociated cultures of the rat hippocampus to test whether pre - exposure of immature neurons to high concentrations of glutamate , N - methyl - D - aspartic acid ( NMDA ) or alpha - amino-3-hydroxy-5-methyl-4-isoxazole - propionic acid ( AMPA ) during a relatively resistant period prevents neurons from dying following a second exposure to the same chemicals after neurons mature and become highly vulnerable to excitatory amino acids ( EAAs ) .
Here , we developed a " two hit " model in dissociated cultures of the rat hippocampus to test whether pre - exposure of immature neurons to high concentrations of glutamate , N - methyl - D - aspartic acid ( NMDA ) or alpha - amino-3-hydroxy-5-methyl-4-isoxazole - propionic acid ( AMPA ) during a relatively resistant period prevents neurons from dying following a second exposure to the same chemicals after neurons mature and become highly vulnerable to excitatory amino acids ( EAAs ) .
Here , we developed a " two hit " model in dissociated cultures of the rat hippocampus to test whether pre - exposure of immature neurons to high concentrations of glutamate , N - methyl - D - aspartic acid ( NMDA ) or alpha - amino-3-hydroxy-5-methyl-4-isoxazole - propionic acid ( AMPA ) during a relatively resistant period prevents neurons from dying following a second exposure to the same chemicals after neurons mature and become highly vulnerable to excitatory amino acids ( EAAs ) .
Here , we developed a " two hit " model in dissociated cultures of the rat hippocampus to test whether pre - exposure of immature neurons to high concentrations of glutamate , N - methyl - D - aspartic acid ( NMDA ) or alpha - amino-3-hydroxy-5-methyl-4-isoxazole - propionic acid ( AMPA ) during a relatively resistant period prevents neurons from dying following a second exposure to the same chemicals after neurons mature and become highly vulnerable to excitatory amino acids ( EAAs ) .
Here , we developed a " two hit " model in dissociated cultures of the rat hippocampus to test whether pre - exposure of immature neurons to high concentrations of glutamate , N - methyl - D - aspartic acid ( NMDA ) or alpha - amino-3-hydroxy-5-methyl-4-isoxazole - propionic acid ( AMPA ) during a relatively resistant period prevents neurons from dying following a second exposure to the same chemicals after neurons mature and become highly vulnerable to excitatory amino acids ( EAAs ) .
Here , we developed a " two hit " model in dissociated cultures of the rat hippocampus to test whether pre - exposure of immature neurons to high concentrations of glutamate , N - methyl - D - aspartic acid ( NMDA ) or alpha - amino-3-hydroxy-5-methyl-4-isoxazole - propionic acid ( AMPA ) during a relatively resistant period prevents neurons from dying following a second exposure to the same chemicals after neurons mature and become highly vulnerable to excitatory amino acids ( EAAs ) .
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