Early experience and serotonin transporter gene variation interact to influence primate CNS function

@article{Bennett2002EarlyEA,
  title={Early experience and serotonin transporter gene variation interact to influence primate CNS function},
  author={Andrew J. Bennett and Klaus-Peter Lesch and Armin Heils and Jeffrey C Long and J G Lorenz and Susan E. Shoaf and Maribeth Champoux and Stephen J. Suomi and Markku Linnoila and James Dee Higley},
  journal={Molecular Psychiatry},
  year={2002},
  volume={7},
  pages={118-122}
}
Nonhuman primates offer unique opportunities to study the effects of genes, environments, and their interaction, on physiology and complex behavior. We examined genotype and early environment contributions to CNS function in a large sample of rhesus monkeys. In humans, length variation of the serotonin (5-HT) transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) that results in allelic variation in 5-HTT expression is associated with decreased serotonergic function and 5-HT-mediated… 
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A low serotonin turnover rate and a high availability of serotonin transporters were associated with reduced response to excessive alcohol intake, anxiety, and impulsive aggression, which may in part be mediated by reduced alcohol-induced sedation.
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References

SHOWING 1-10 OF 45 REFERENCES
In vivo association between alcohol intoxication, aggression, and serotonin transporter availability in nonhuman primates.
TLDR
In adult nonhuman primates who underwent early developmental stress, variables indicating a low serotonin turnover rate were associated with behavior patterns similar to those predisposing to early-onset alcoholism among humans.
Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels.
TLDR
Serotonin transporter binding sites were regulated in a region-specific and substance-specific pattern, which was not simply a local response to functional blockade, and it is possible that serotonin transporter promoter genotype may play a complex role in chronic ethanol dependence.
Allelic Variation of Human Serotonin Transporter Gene Expression
TLDR
Mood, emotion, cognition, and motor functions as well as circadian and neuroendocrine rhythms, including food intake, sleep, and reproductive activity, are modulated by the midbrain raphe serotonin (5‐HT) system and allele‐dependent differential 5‐HTT promoter activity may play a role in the expression and modulation of complex traits and behavior.
Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets.
TLDR
5-HT uptake findings support a functional difference in the two 5-HTTLPR variants, reinforcing their attractiveness as candidate genes in neuropsychiatric research.
Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample.
TLDR
These results help to define specific personality features reproducibly associated with 5-HTTLPR genotype, enhancing the attractiveness of the five-factor personality model in genetic research on complex behavioral dimensions.
Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region
Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting
Pharmacogenetics and the serotonin system: initial studies and future directions.
Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects.
TLDR
There was no main effect of genotype on harm avoidance and neuroticism scores in subjects with diagnoses of a personality disorder or substance dependence, and interactions were observed between sex and promoter system genotype and between race and promoterSystem genotype.
No Association between the Serotonin Transporter-Linked Promoter Region Polymorphism and Either Schizophrenia or Density of the Serotonin Transporter in Human Hippocampus
TLDR
5-HTTLPR genotype neither confers an increased susceptibility for schizophrenia nor dictates the expression of the 5-HTT in the human hippocampus, according to the parameters of [3H]paroxetine binding to the hippocampus.
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