Early evolution of the venom system in lizards and snakes

@article{Fry2006EarlyEO,
  title={Early evolution of the venom system in lizards and snakes},
  author={Bryan Grieg Fry and Nicol{\'a}s Vidal and Janette A. Norman and Freek J. Vonk and Holger Scheib and Suwat Ramjan and Sanjaya Chinthana Kuruppu and K Fung and S. Blair Hedges and Michael K. Richardson and Wayne C. Hodgson and Vera Ignjatovic and Robyn Summerhayes and Elazar Kochva},
  journal={Nature},
  year={2006},
  volume={439},
  pages={584-588}
}
Among extant reptiles only two lineages are known to have evolved venom delivery systems, the advanced snakes and helodermatid lizards (Gila Monster and Beaded Lizard). Evolution of the venom system is thought to underlie the impressive radiation of the advanced snakes (2,500 of 3,000 snake species). In contrast, the lizard venom system is thought to be restricted to just two species and to have evolved independently from the snake venom system. Here we report the presence of venom toxins in… 
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References

SHOWING 1-10 OF 43 REFERENCES
The evolution of venom-delivery systems in snakes
TLDR
Several major morphological changes occurred early in colubroid evolution: a Duvernoy's gland evolved, the posterior maxillary teeth became specialized relative to the anterior max- illary teeth, and the attachment of the pterygoideus muscle moved forward to a position associated with the posteriormaxillary teeth.
Molecular Evolution and Phylogeny of Elapid Snake Venom Three-Finger Toxins
TLDR
The purpose of this study was to investigate the long-term evolutionary patterns exhibited by these snake venom toxins to understand the mechanisms by which they diversified into a large, biochemically diverse, multigene family.
Assembling an arsenal: origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences.
TLDR
Analysis of snake venom toxin families provides strong additional evidence that venom evolved once, at the base of the advanced snake radiation, rather than multiple times in different lineages, with these toxins also present in the venoms of the "colubrid" snake families.
Analysis of Colubroidea snake venoms by liquid chromatography with mass spectrometry: evolutionary and toxinological implications.
TLDR
The large body of data on molecular masses and retention times thus assembled demonstrates a hitherto unsuspected diversity of toxins in all lineages, having implications ranging from clinical management of envenomings to venom evolution to the use of isolated toxins as leads for drug design and development.
Isolation of a Neurotoxin (α-colubritoxin) from a Nonvenomous Colubrid: Evidence for Early Origin of Venom in Snakes
TLDR
The first complete amino acid sequence of a colubrid toxin is provided, which is called α-colubritoxin, isolated from the Asian ratsnake Coelognathusradiatus, an archetypal nonvenomous snake as sold in pet stores, to support the role of venom as a key evolutionary innovation in the early diversification of advanced snakes and provide evidence that forces a fundamental rethink of the very concept of nonvenoms.
COLUBROID SYSTEMATICS: EVIDENCE FOR AN EARLY APPEARANCE OF THE VENOM APPARATUS FOLLOWED BY EXTENSIVE EVOLUTIONARY TINKERING
TLDR
The presence of serous secretory cells in the supralabial region and of a differentiated maxillary dentition within the most basal extant lineages of advanced snakes strongly suggest that the venom apparatus is a synapomorphy of the Colubroidea and that its absence in a few “Colubridae” results from secondary losses.
From genome to "venome": molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins.
  • B. Fry
  • Biology
    Genome research
  • 2005
TLDR
This study revealed that the toxin types, where the ancestral protein was extensively cysteine cross-linked, were the ones that flourished into functionally diverse, novel toxin multigene families.
Molecular phylogenetics of squamata: the position of snakes, amphisbaenians, and dibamids, and the root of the squamate tree.
TLDR
A molecular phylogenetic study of 69 squamate species suggests that similar states in Sphenodon and Iguania result from homoplasy, and species previously placed in Scleroglossa, Varanoidea, and several other higher taxa do not form monophyletic groups.
At the feet of the dinosaurs: the early history and radiation of lizards
  • S. Evans
  • Geography, Environmental Science
    Biological reviews of the Cambridge Philosophical Society
  • 2003
TLDR
Current understanding of the first 150 million years of squamate evolution in the light of the new data and changing ideas is examined, predicting that squamates had evolved by at least the middle Triassic, and diversified into existing major lineages before the end of this period.
Molecular evidence for a terrestrial origin of snakes
  • N. Vidal, S. Hedges
  • Environmental Science
    Proceedings of the Royal Society of London. Series B: Biological Sciences
  • 2004
TLDR
It is shown that DNA sequence evidence does not support a close relationship between snakes and monitor lizards, and thus supports a terrestrial origin of snakes.
...
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