Early events of B-cell receptor signaling are not essential for the proliferation and viability of AIDS-related lymphoma

Abstract

We have evaluated whether targeting the Src family kinase cascade, an early component of B-cell receptor (BCR) signaling, is an effective strategy to treat AIDS-related lymphoma (ARL). Src kinases are activated after ligation of the BCR and they phosphorylate downstream signaling proteins in tyrosine residues relaying B-cell signaling cascades that lead to B cell activation and proliferation. These kinases play an important role in lymphoma pathogenesis. We have shown that Src kinases are constitutively active in diffuse large cell lymphoma (DLBCL) cells occurring in immunocompetent individuals and inhibition of these kinases using dasatinib inhibits proliferation of the lymphoma cells.

DOI: 10.1186/1750-9378-4-S2-P13

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@inproceedings{Lu2009EarlyEO, title={Early events of B-cell receptor signaling are not essential for the proliferation and viability of AIDS-related lymphoma}, author={Phillip K. Lu and Chun Yang and Ilaria Guasparri and Whitney Harrington and Y. Wang and Ethels Cesarman}, booktitle={Infectious Agents and Cancer}, year={2009} }