Early events in preprotein recognition in E. coli: interaction of SRP and trigger factor with nascent polypeptides.

@article{Valent1995EarlyEI,
  title={Early events in preprotein recognition in E. coli: interaction of SRP and trigger factor with nascent polypeptides.},
  author={Quido A. Valent and Debra A. Kendall and Stephen High and Gerardus Christiaan Marie Kusters and Bauke Oudega and Joen Luirink},
  journal={The EMBO journal},
  year={1995},
  volume={14 22},
  pages={
          5494-505
        }
}
In Escherichia coli, components of a signal recognition particle (SRP) and its receptor have been identified which appear to be essential for efficient translocation of several proteins. In this study we use cross-linking to demonstrate that E. coli SRP interacts with a variety of nascent presecretory proteins and integral inner membrane proteins. Evidence is presented that the interaction is correlated with the hydrophobicity of the core region of the signal sequence and thereby with its… CONTINUE READING

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