Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry

@article{McClain2005EarlyEI,
  title={Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry},
  author={Micah T. McClain and Latisha D. Heinlen and Gregory J Dennis and Jon Roebuck and John Barker Harley and Judith A James},
  journal={Nature Medicine},
  year={2005},
  volume={11},
  pages={85-89}
}
The origins of autoimmunity in systemic lupus erythematosus (SLE) are thought to involve both genetic and environmental factors. To identify environmental agents that could potentially incite autoimmunity, we have traced the autoantibody response in human SLE back in time, prior to clinical disease onset, and identified the initial autoantigenic epitope for some lupus patients positive for antibodies to 60 kDa Ro. This initial epitope directly cross-reacts with a peptide from the latent viral… CONTINUE READING
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Autoantibodies are present years before the clinical onset of systemic lupus erythematosus

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