Early events in TNF signaling: a story of associations and dissociations.

  title={Early events in TNF signaling: a story of associations and dissociations.},
  author={Bryant G. Darnay and Bharat Bhushan Aggarwal},
  journal={Journal of leukocyte biology},
  volume={61 5},
At the cellular level, the multifunctional cytokine tumor necrosis factor (TNF) modulates growth and activates genes through various intermediates, including protein kinases, protein phosphatases, reactive oxygen intermediates, phospholipases, proteases, sphingomyelinases, and transcription factors. Unlike many cytokine receptors, however, the cytoplasmic domain (CD) of the TNF receptors lacks an intrinsic protein kinase activity and yet on interaction with ligand it phosphorylates various… CONTINUE READING
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