Early events in RNA folding.

  title={Early events in RNA folding.},
  author={D Thirumalai and Nayoung Lee and Sarah A Woodson and Dmitri Klimov},
  journal={Annual review of physical chemistry},
We describe a conceptual framework for understanding the way large RNA molecules fold based on the notion that their free-energy landscape is rugged. A key prediction of our theory is that RNA folding can be described by the kinetic partitioning mechanism (KPM). According to KPM a small fraction of molecules folds rapidly to the native state whereas the remaining fraction is kinetically trapped in a low free-energy non-native state. This model provides a unified description of the way RNA and… CONTINUE READING

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