Early events associated to the oral co-administration of type II collagen and chitosan: induction of anti-inflammatory cytokines.

@article{Porporatto2004EarlyEA,
  title={Early events associated to the oral co-administration of type II collagen and chitosan: induction of anti-inflammatory cytokines.},
  author={Carina Porporatto and Ismael D Bianco and Ana Mar{\'i}a Cabanillas and Silvia Graciela Correa},
  journal={International immunology},
  year={2004},
  volume={16 3},
  pages={433-41}
}
Oral administration of an antigen can result in local and systemic priming or tolerance and the basis of this dichotomy is poorly understood. The intestinal microenvironment, and factors such as nature of the antigen, dose, genetic background, uptake and concentration of the antigen that gain access to the internal milieu via the mucosa influence these active immunologic processes. Chitosan is a biocompatible natural polysaccharide able to promote the transmucosal absorption of peptides and… CONTINUE READING