Early establishment of cerebral dysfunction after portacaval shunting.

@article{Mans1990EarlyEO,
  title={Early establishment of cerebral dysfunction after portacaval shunting.},
  author={Anke M. Mans and M. Regina Dejoseph and Donald W. Davis and Juan Vina and Richard R. Hawkins},
  journal={The American journal of physiology},
  year={1990},
  volume={259 1 Pt 1},
  pages={E104-10}
}
Portacaval shunting in rats results in brain dysfunction, as indicated by reduced energy metabolism and behavioral abnormalities, as well as many biochemical changes in plasma and brain. No etiological connections have been made between these findings, which have been studied mainly 2 wk or more after shunting. To determine how soon the various abnormalities occur and which are associated temporally with the decrease in brain glucose use, we studied shunted and sham-operated rats between 6 h… CONTINUE READING
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