Early epirubicin-induced myocardial dysfunction revealed by serial tissue Doppler echocardiography: correlation with inflammatory and oxidative stress markers.

@article{Mercuro2007EarlyEM,
  title={Early epirubicin-induced myocardial dysfunction revealed by serial tissue Doppler echocardiography: correlation with inflammatory and oxidative stress markers.},
  author={Giuseppe Mercuro and Christian Cadeddu and Alessandra Piras and M. Dessi and Clelia Madeddu and Martino Deidda and Roberto Serpe and E. Rabino Massa and Giovanni Mantovani},
  journal={The oncologist},
  year={2007},
  volume={12 9},
  pages={1124-33}
}
A phase II, open, nonrandomized trial was carried out in a group of epirubicin-treated patients with cancer at different sites with the aim of detecting early preclinical changes that are predictive of the risk for heart failure. All patients underwent conventional echocardiography, as well as tissue Doppler imaging (TDI) with strain (sigma) and strain rate (SR), a very accurate technique for detecting minimal changes in cardiac left ventricular (LV) function. Moreover, echocardiographic… CONTINUE READING