Pharmacological inhibition of type I interferon signaling protects mice against lethal sepsis.
- Lien Dejager, Sofie Vandevyver, +5 authors Claude Libert
- The Journal of infectious diseases
- 2014
Highly Influenced
5 Excerpts
Early enhanced local neutrophil recruitment in peritonitis-induced sepsis improves bacterial clearance and survival.
- Published 2010 in Journal of immunology
Abstract
Neutrophils are critical for the rapid eradication of bacterial pathogens, but they also contribute to the development of multiple organ failure in sepsis. We hypothesized that increasing early recruitment of neutrophils to the focus of infection will increase bacterial clearance and improve survival. Sepsis was induced in mice, using cecal ligation and… (More)