Early enhanced local neutrophil recruitment in peritonitis-induced sepsis improves bacterial clearance and survival.

Abstract

Neutrophils are critical for the rapid eradication of bacterial pathogens, but they also contribute to the development of multiple organ failure in sepsis. We hypothesized that increasing early recruitment of neutrophils to the focus of infection will increase bacterial clearance and improve survival. Sepsis was induced in mice, using cecal ligation and… (More)
DOI: 10.4049/jimmunol.1002300

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